: What is the mst ikey diagnsi    n examinatin:
                                  -this disease shws geneaized (systemi) symptms.  Fig 10.25
  1- Feve
  2- jints: Jint invvement is the mst mmn inia feate,  sma jint pyathpathy .
  3- skin:   
      eent phtsensitive ash , in bttefy distibtin n the heeks f the fae and ass the bidge f the nse 
      Apeia 
      d
  4- The ngs: intemittent peiti dismft.
  5- The kidneys: pteinia
  6- The nevs system: migaine ike headahes.
  7- The eyes: njntivitis.
  8- The gastintestina tat: 
      Nasea.
      Abdmen pain.
  Investigatin: 
  1.       Maked anemia “atimmne hemyti anemia”
  2.       Psitive -eative ptein.
  3.       High eve ANA (antinea antibdy).
  4.       High eve f anti-DNA antibdies.
   
   2: What is the etigy f this disease?
  nknwn, bt thee is pedispsing fats. The mst ikey pedispsing fat in this nditin is “sex hmne stats” 
  Fat :
  1)      Heedity.
  2)      Genetis
  3)      mpement
  4)      Sex hmne stats: pemenpasa wmen , mae with kinefete (XXY) 
  5)      Dg 
  6)      V
  7)      Vises 
   3: What ae the immngia fats assiated with this disease?
  1.       Ativatin f B e ests eventay in an inease f antibdies.
  2.       Faie t emve immne mpexes fm the iatin eads t depsitin f mpexes in the tisse asing damage.
  3.       Impaied T e egatin whih ests in me desttin and me ativatin t the es e.g. B e.
  4.       Abnma ytkine pdtin (I-1 and I-2) whih stimates the T es.
  5.       TNF-a pmte pymphisms.
   4: What is the pathgenesis f the disease?
     SE is a faie t maintain sef-teane “atimmne disease” and faie t ea nea mateia fm apptti es and nea mateia being in exess and pssiby in ateed fm. These nea mateia is taken by antigen pesenting e e.g. maphage whih pesented t T e (whih st its teane against sef-antigen), T e wi stimate B-e pding antibdies against nea antigens whih ests in damage.
   
     Beside, ANAs an eat with nei f damaged es ead t hmatin hanges t pde s-aed E bdies  hematxyin bdies.