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الموضوع: نماذج لأسأله وامتحانات في علم المناعه احد مساقات الصيدله)

  1. #1
    تاريخ التسجيل
    Dec 2007
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    فلسطين48
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    109

    نماذج لأسأله وامتحانات في علم المناعه احد مساقات الصيدله)

    السلام عليكم ورحمة الله وبركاته ,
    اضع بين يديكم بعض الاسئله التابعه لعلم المناعه لعل وعسى ان يكون بها منفعه لكم ,


    1
    First-line the defense against antigenic insult




    adaptive immune system



    innate immune system
    2
    Adaptive Immune Response(s):




    antibody production



    lymphocyte activation



    both



    neither
    3
    Generation of specific immunity requires antigen-presenting cells, APCs, including:




    B lymphocytes



    macrophages



    Langerhans cells



    A & B



    A,B & C
    4
    Produced by TH1 subsets of T helper lymphocytes:




    interferon-gamma



    interleukin-2



    tumor necrosis factor beta



    A & B



    A, B & C
    5
    Typically associated with B cell proliferation and differentiation into antibody-secreting plasma cells




    tumor necrosis factor beta



    interferon-gamma



    IL-4 (interleukin 4)



    IL-2 (interleukin 2)



    all of the above
    6
    T helper lymphocytes -- regulate each other; this substance produced by TH1cells inhibits TH2 cellular proliferation:




    interleukin-2



    tumor necrosis factor beta



    interferon-gamma



    IL-4



    IL-6
    7
    Extracellular bacteria promote elaboration of:




    TH1 cytokines



    TH2 cytokines
    8
    Intracellular organisms (e.g. Mycobacterium) promote production of:




    TH1 cytokines



    TH2 cytokines
    9
    Activated cytotoxic T cells induce target cell death (virus-infected cells) by:




    Fas-Fas ligand apotosis pathway



    lytic granule enzymes



    perforin



    all of the above
    10
    Hypersensitivity: cross-linking of membrane-bound IgE on blood basophils or tissue mast cells by antigen




    Type I



    Type II



    Type III
    11
    Hemolytic disease of the newborn:




    Immediate Hypersensitivity Type I



    Delayed Hypersensitivity



    Immediate Hypersensitivity Type II



    Immediate Hypersensitivity Type III
    12
    Associated with elevated levels of antigen-antibody complexes, which cause tissue damage; complement activation results in anaphylatoxic and chemotactic activities:




    Immediate Hypersensitivity Type III



    Immediate Hypersensitivity Type II



    Delayed Hypersensitivity



    Immediate Hypersensitivity Type I
    13
    Administration of penicillin to allergic patients:




    Immediate Hypersensitivity Type I



    Immediate Hypersensitivity Type II



    Immediate Hypersensitivity Type III
    14
    Effective in eliminating infections caused by intracellular pathogens such as Leishmania species:




    Immediate Hypersensitivity Type I



    Immediate Hypersensitivity Type II



    Immediate Hypersensitivity Type III



    Delayed Hypersensitivity
    15
    Examples of autoimmune diseases




    rheumatoid arthritis



    insulin-dependent diabetes mellitus



    systemic lupus erythematosis



    A & C



    A, B & C
    أعلى النموذج

    1
    Example of first-class of hormonal agents noted to have lipolytic properties:




    cyclosporine



    prednisone (Deltasone)



    tacrolimus



    IFN-alpha



    thalidomide
    2
    Glucocorticoid effects:




    inhibition of leukotriene production



    inhibition of prostaglandins



    increased chemotaxis



    A & B



    A, B & C
    3
    Effective in lowering incidents of rejection in infectious complications in transplant patients:




    azathioprine (Imuran)



    prednisone (Deltasone)



    antilymphocyte antibodies



    cyclosporine (Sandimmune, Neoral)



    all the above
    4
    Tests of immunocompetency:-- measurements




    in vitro IL-2 stimulation of lymphokine activated killer cell production



    in vitro lymphocyte profilerative responses to mitogens



    erythropoiesis



    A & B



    A, B & C
    5
    About two-thirds of children with early diabetic symptoms can discontinue or reduce insulin treatment within about six weeks after starting treatment with this drug:




    tacrolimus



    interferon



    cyclosporine (Sandimmune, Neoral)



    prednisone (Deltasone) and



    thalidomide
    6
    This immunosuppressant antibiotic commonly approved for use in liver transplantation, is 10 to 100 times more potent than cyclosporine in inhibiting immune responses:




    interferon-gamma



    prednisone (Deltasone)



    tacrolimus (FK 506)



    A & B



    A, B & C
    7
    Autoimmune (Type II) drug reaction:





    penicillin



    sulfonamides



    iodides



    phenytoin (Dilantin)



    hydralazine (Apresoline)
    8
    Implicated in initiation of hypersensitivity vasculitis; a Type III vasculitic reaction:




    sulfonamides



    penicillin



    thiouracil



    anticonvulsants



    all the above
    9
    Blockade of mediator release following exposure of sensitized tissue mast cells or blood basophils to drugs that initiate Type I drug allergic reactions:




    isoproterenol (Isuprel)



    antihistamines



    theophylline



    A & C



    A, B & C
    10
    Example of immunostimulatory cytokine that may be useful in cancer immunotherapy




    levamisole



    BCG



    IFN-alpha



    IL-2



    none of the above
    11
    For synthesized for treating parasitic infections, this drug is now FDA approved for clinical use in the treatment of Dukes class C colorectal cancer after surgery:




    inosiplex



    thymopoietin



    levamisole



    BCG



    IGIV
    12
    Alkylating agent; destroys proliferating lymphoid cells; in low doses -- for effective against autoimmune disorders including systemic lupus erythematosus




    azathioprine (Imuran)



    methotrexate



    cyclophosphamide (Cytoxan)



    antilymphocyte globulin (ALG)



    all the above
    13
    Cytotoxic agents with immunosuppressive properties:




    cyclophosphamide (Cytoxan)



    vincristine (Oncovin)



    methotrexate



    cytarabine (ARA-C)



    all the above
    14
    Type 1 immediate hypersensitivity:




    due to elevated levels of antigen-antibody complexes



    stems from cross-linking of membrane-bound IgE on blood basophils or tissue mast cells by antigen



    follows from formation of antigen- antibody complexes between foreign antigen and IgM or IgG immunoglobulins



    tissue damage due to influx of antigen-nonspecific inflammatory cells (macrophages and neutrophils)
    15
    Autoimmune disorder: associated with antibodies made against self DNA, red blood cells, histones, platelets




    rheumatoid arthritis



    systemic lupus erythematosus



    insulin dependent diabetes

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    Congenitally-acquired immunodeficiency disease
    ???Class I MHC moleculescorticosteroidsClass II MHC moleculesdelayed hypersensitivityhuman immunodeficiency virusDiGeorge's syndromeType II immediate hypersensitivityTH2activated cytotoxic T celleffectors of cell-mediated immunitysevere combined immunodeficiency disease (SCID)Type I hypersensitivityeffectors of humoral immunity
    X
    adenosine deaminase deficiency
    ???Class I MHC moleculescorticosteroidsClass II MHC moleculesdelayed hypersensitivityhuman immunodeficiency virusDiGeorge's syndromeType II immediate hypersensitivityTH2activated cytotoxic T celleffectors of cell-mediated immunitysevere combined immunodeficiency disease (SCID)Type I hypersensitivityeffectors of humoral immunity
    X
    strong tropism for CD4+ helper T cells
    ???Class I MHC moleculescorticosteroidsClass II MHC moleculesdelayed hypersensitivityhuman immunodeficiency virusDiGeorge's syndromeType II immediate hypersensitivityTH2activated cytotoxic T celleffectors of cell-mediated immunitysevere combined immunodeficiency disease (SCID)Type I hypersensitivityeffectors of humoral immunity
    X
    reaction effective in eliminating infections caused by intracellular pathogens (e.g. Leishmania)
    ???Class I MHC moleculescorticosteroidsClass II MHC moleculesdelayed hypersensitivityhuman immunodeficiency virusDiGeorge's syndromeType II immediate hypersensitivityTH2activated cytotoxic T celleffectors of cell-mediated immunitysevere combined immunodeficiency disease (SCID)Type I hypersensitivityeffectors of humoral immunity
    X
    cell type associated with cell-mediated immunity
    ???Class I MHC moleculescorticosteroidsClass II MHC moleculesdelayed hypersensitivityhuman immunodeficiency virusDiGeorge's syndromeType II immediate hypersensitivityTH2activated cytotoxic T celleffectors of cell-mediated immunitysevere combined immunodeficiency disease (SCID)Type I hypersensitivityeffectors of humoral immunity
    X
    activated lymphocytes
    ???Class I MHC moleculescorticosteroidsClass II MHC moleculesdelayed hypersensitivityhuman immunodeficiency virusDiGeorge's syndromeType II immediate hypersensitivityTH2activated cytotoxic T celleffectors of cell-mediated immunitysevere combined immunodeficiency disease (SCID)Type I hypersensitivityeffectors of humoral immunity
    X
    antibodies
    ???Class I MHC moleculescorticosteroidsClass II MHC moleculesdelayed hypersensitivityhuman immunodeficiency virusDiGeorge's syndromeType II immediate hypersensitivityTH2activated cytotoxic T celleffectors of cell-mediated immunitysevere combined immunodeficiency disease (SCID)Type I hypersensitivityeffectors of humoral immunity
    X
    IL-4, IL-5, IL-6 produced by this subset of T cells
    ???Class I MHC moleculescorticosteroidsClass II MHC moleculesdelayed hypersensitivityhuman immunodeficiency virusDiGeorge's syndromeType II immediate hypersensitivityTH2activated cytotoxic T celleffectors of cell-mediated immunitysevere combined immunodeficiency disease (SCID)Type I hypersensitivityeffectors of humoral immunity
    X
    present mainly fragments of cellular antigens (e.g. virus or tumor antigens) process through Golgi apparatus
    ???Class I MHC moleculescorticosteroidsClass II MHC moleculesdelayed hypersensitivityhuman immunodeficiency virusDiGeorge's syndromeType II immediate hypersensitivityTH2activated cytotoxic T celleffectors of cell-mediated immunitysevere combined immunodeficiency disease (SCID)Type I hypersensitivityeffectors of humoral immunity
    X
    present antigen fragments from internalized and enzymatically digested foreign antigens
    ???Class I MHC moleculescorticosteroidsClass II MHC moleculesdelayed hypersensitivityhuman immunodeficiency virusDiGeorge's syndromeType II immediate hypersensitivityTH2activated cytotoxic T celleffectors of cell-mediated immunitysevere combined immunodeficiency disease (SCID)Type I hypersensitivityeffectors of humoral immunity
    X
    Immediate hypersensitivity type associated with hemolytic disease in the newborn
    ???Class I MHC moleculescorticosteroidsClass II MHC moleculesdelayed hypersensitivityhuman immunodeficiency virusDiGeorge's syndromeType II immediate hypersensitivityTH2activated cytotoxic T celleffectors of cell-mediated immunitysevere combined immunodeficiency disease (SCID)Type I hypersensitivityeffectors of humoral immunity
    X
    Immediate hypersensitivity reaction associated with asthma, hay fever, hives -- following blood basophil or tissue mast cell degranulation
    ???Class I MHC moleculescorticosteroidsClass II MHC moleculesdelayed hypersensitivityhuman immunodeficiency virusDiGeorge's syndromeType II immediate hypersensitivityTH2activated cytotoxic T celleffectors of cell-mediated immunitysevere combined immunodeficiency disease (SCID)Type I hypersensitivityeffectors of humoral immunity
    X
    First-class of hormonal agents recognized to possess lympholytic properties


    Immunopharmacology
    This is a self-grading exam. Answers are entered by clicking the button corresponding to your selection. The examination is scored by clicking 'Grade Test' at the bottom of the form. Correct answers are found through hyperlinks at the bottom of the page.


    أعلى النموذج

    Question # 1 (Multiple Choice) Structural analog/antimetabolite: cytotoxic immunosuppressive drug:
    A) vincristine
    B) cyclophosphamide
    C) azathioprine
    D) none of the above

    Question # 2 (Multiple Choice) Immunomodulatory sedative drugs used in the management of some forms of leprosy; also effective in managing skin manifestations of lupus erythematosus
    A) tacrolimus
    B) cyclophosphamide
    C) thalidomide
    D) buproprion
    E) diazepam

    Question # 3 (Multiple Choice) Drug of choice in treating autoimmune hemolytic anemia:
    A) cyclophosphamide plus factor XIII
    B) Rho(D) immune globulin
    C) prednisone
    D) OKT3 monoclonal antibody
    E) cyclosporine

    Question # 4 (Multiple Choice) Interferes with cell cycle of activated lymphoid cells;example of the first class of hormonal agents recognized have lympholytic properties:
    A) cyclosporine
    B) tacrolimus
    C) IFN-alpha
    D) dexamethasone
    E) 15-desoxyspergualin

    Question # 5 (Multiple Choice) Useful in management of idiopathic thrombocytopenic purpura refractory to prednisone
    A) dactinomycin
    B) vincristine
    C) cyclophosphamide
    D) azathioprine
    E) all of the above

    Question # 6 (Multiple Choice) Drug of choice in treating hemolytic anemia of the newborn:
    A) cyclosporine
    B) prednisone
    C) OKT3 monoclonal antibody
    D) tacrolimus
    E) Rho(D) immune globulin

    Question # 7 (Multiple Choice) Clinical uses of interferon:
    A) cancer treatment
    B) multiple sclerosis
    C) both
    D) neither

    Question # 8 (True/False) Type 1 hypersensitivity: cross-linking of membrane-bound IgE on blood basophils or tissue mast cells by antigen
    A) true
    B) false

    Question # 9 (Multiple Choice) immunomodulating agents:
    A) thymosin
    B) interferon beta
    C) interferon-gamma
    D) TNF alpha
    E) all the above

    Question # 10 (True/False) Class 1 MHC molecules present mainly fragments of cellular antigens
    A) true
    B) false

    Question # 11 (Multiple Choice) Inhibits antigen recognition of B-cell
    A) prednisone
    B) azathioprine
    C) methotrexate
    D) Rho(D) immune globulin
    E) tacrolimus

    Question # 12 (Multiple Choice) Antilymphocyte antibodies:
    A) binds to the surface of T cells
    B) acts mainly on small, long-lived peripheral lymphocytes
    C) may be used in induction of immunosuppression
    D) may be obtained by hybridoma technique for monoclonal antibody generation
    E) all of the above

    Question # 13 (Multiple Choice) Clinical uses of immunosuppressive drugs:
    A) organ transplantation
    B) hemolytic disease of the newborn
    C) autoimmune disorders
    D) A & C
    E) A, B & C
    أسفل النموذج


  2. #2
    تاريخ التسجيل
    Sep 2007
    الدولة
    مدينة احلامي
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    222

    افتراضي

    يعطيك العافيه يارب_شو هاد مناااعه الله يرحم ايامك ياا.............مابدي احكي اسمه هاد دكتوري اللي عطاني الماده والله ماده ممتعه بس...ما بدي كمل...
    ع كلا مشكور اخي ع المجهود

  3. #3
    تاريخ التسجيل
    Nov 2007
    الدولة
    السـعوديــــة - طيــ أطيب البلدان ـبة
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    47

    افتراضي

    تشكوراااات حبيبتي .. جزاك الله ألف خير

  4. #4
    تاريخ التسجيل
    Sep 2007
    الدولة
    Jordan & palestine
    المشاركات
    602

    افتراضي

    يسلمووو يا محاجنة
    صحيح على سيرة الimmune د.مطالقة بسلم عليك سلام خصوصي
    تحياتي

  5. #5

    افتراضي

    تسلم يامحاجنه وماتقصر

  6. #6

    افتراضي

    يسلموووووووووووووووووووووووووووووووووووووووووووووووووو


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