{"id":2159,"date":"2013-09-28T10:15:34","date_gmt":"2013-09-28T07:15:34","guid":{"rendered":"http:\/\/www.tbeeb.net\/hma\/?p=2159"},"modified":"2021-10-12T08:44:43","modified_gmt":"2021-10-12T05:44:43","slug":"%d8%a7%d9%84%d8%b9%d9%84%d8%a7%d8%ac-%d8%a7%d9%84%d9%87%d8%b1%d9%85%d9%88%d9%86%d9%8a-%d9%84%d8%b3%d8%b1%d8%b7%d8%a7%d9%86-%d8%a7%d9%84%d8%ab%d8%af%d9%8a-%d8%ac23","status":"publish","type":"post","link":"https:\/\/www.tbeeb.net\/health\/%d8%a7%d9%84%d8%b9%d9%84%d8%a7%d8%ac-%d8%a7%d9%84%d9%87%d8%b1%d9%85%d9%88%d9%86%d9%8a-%d9%84%d8%b3%d8%b1%d8%b7%d8%a7%d9%86-%d8%a7%d9%84%d8%ab%d8%af%d9%8a-%d8%ac23\/","title":{"rendered":"\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u064a \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a"},"content":{"rendered":"<p>\u064a\u062a\u0623\u0644\u0641 \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0645\u0646 \u0645\u062c\u0645\u0648\u0639\u0629 \u0643\u0628\u064a\u0631\u0629 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(Adrenals) \u0627\u0644\u062a\u064a \u062a\u0646\u062a\u062c \u0648\u062a\u0641\u0631\u0632 \u0628\u0631\u0648\u062a\u064a\u0646\u0627\u062a \u062a\u0633\u062a\u0637\u064a\u0639 \u062a\u062d\u0648\u064a\u0644 \u0645\u0648\u0627\u062f \u0647\u0631\u0645\u0648\u0646\u064a\u0629 \u0630\u0643\u0648\u0631\u064a\u0629 \u0627\u0646\u062f\u0631\u0648\u0633\u062a\u064a\u0646\u062f\u064a\u0648\u0646 \u0625\u0644\u0649 \u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0646\u0633\u0627\u0626\u064a\u0629 \u0623\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u0641\u064a \u0627\u0644\u062f\u0645 \u0648\u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u0637\u0631\u0641\u064a\u0629.<\/p>\n<h2>\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u064a \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0627\u0644\u0645\u0646\u062a\u0634\u0631<\/h2>\n<p>&#8211; \u0645\u0627 \u0647\u064a \u0627\u0644\u062e\u0637\u0648\u0627\u062a \u0627\u0644\u0645\u062a\u0628\u0639\u0629 \u0644\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u064a \u062d\u0633\u0628 \u0627\u0644\u0639\u0645\u0631\u061f<\/p>\n<h2>\u0623 &#8211; \u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0631\u064a\u0636\u0629 \u0627\u0644\u0635\u063a\u064a\u0631\u0629 \u0641\u064a \u0627\u0644\u0639\u0645\u0631 \u062f\u0648\u0646 \u0633\u0646 \u0627\u0646\u0642\u0637\u0627\u0639 \u0627\u0644\u062d\u064a\u0636 Menopause<\/h2>\n<p>\u0623\u0648\u0644\u0627\u064b: \u0642\u0637\u0639 \u0645\u0635\u062f\u0631 \u0625\u0646\u062a\u0627\u062c \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0627\u0644\u0646\u0633\u0627\u0626\u064a\u0629<\/p>\n<p>\u0628\u0645\u0627 \u0623\u0646 \u0627\u0644\u0645\u0628\u064a\u0636\u064a\u0646 \u064a\u0646\u062a\u062c\u0627\u0646 \u0627\u0644\u0627\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u0628\u0643\u0645\u064a\u0627\u062a \u0639\u0627\u0644\u064a\u0629 \u0641\u064a \u0647\u0630\u0627 \u0627\u0644\u0639\u0645\u0631\u060c \u064a\u062c\u0628 \u0623\u0648\u0644\u0627\u064b \u0642\u0637\u0639 \u0645\u0635\u062f\u0631 \u0627\u0644\u0627\u0646\u062a\u0627\u062c.<\/p>\n<p>\u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u0623\u0648\u0644\u0649: \u0642\u0637\u0639 \u0645\u0635\u062f\u0631 \u0627\u0644\u0627\u0633\u062a\u0631\u0648\u062c\u064a\u0646\u0627\u062a. \u064a\u062a\u0645 \u0630\u0644\u0643 \u0625\u0645\u0627 \u0628\u0625\u0633\u062a\u0626\u0635\u0627\u0644 \u0627\u0644\u0645\u0628\u064a\u0636 \u0628\u0648\u0627\u0633\u0637\u0629 \u0639\u0645\u0644\u064a\u0629 \u062c\u0631\u0627\u062d\u064a\u0629 \u0628\u0633\u064a\u0637\u0629 \u064a\u062a\u0645 \u0625\u062c\u0631\u0627\u0626\u0647\u0627 \u062d\u062f\u064a\u062b\u0627\u064b \u0628\u0648\u0627\u0633\u0637\u0629 \u062c\u0631\u0627\u062d\u0629 \u0627\u0644\u0645\u0646\u0638\u0627\u0631 \u0648\u0646\u062a\u064a\u062c\u062a\u0647\u0627 \u062a\u0643\u0648\u0646 \u0641\u0648\u0631\u064a\u0629.<\/p>\n<p>\u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629: \u062a\u0648\u0642\u064a\u0641 \u0627\u0644\u0645\u0628\u064a\u0636\u064a\u0646 \u0639\u0646 \u0627\u0644\u0639\u0645\u0644 \u0628\u0648\u0627\u0633\u0637\u0629 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0634\u0639\u0627\u0639\u064a \u062d\u064a\u062b \u064a\u0643\u0648\u0646 \u0627\u0644\u0645\u0641\u0639\u0648\u0644 \u062a\u062f\u0631\u064a\u062c\u064a\u0627\u064b \u0648\u0627\u0644\u0646\u062a\u064a\u062c\u0629 \u062a\u0628\u062f\u0623 \u0628\u0639\u062f \u0634\u0647\u0631\u064a\u0646 \u0623\u0648 \u062b\u0644\u0627\u062b\u0629. \u0648\u064a\u0633\u062a\u062d\u0633\u0646 \u0627\u0644\u062a\u0623\u0643\u062f \u0645\u0646 \u0646\u062a\u064a\u062c\u0629 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0634\u0639\u0627\u0639\u064a \u0639\u0646 \u0637\u0631\u064a\u0642 \u0641\u062d\u0648\u0635\u0627\u062a \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0641\u064a \u0627\u0644\u062f\u0645 \u0644\u0623\u0646\u0647\u0627 \u0642\u062f \u0644\u0627 \u062a\u0646\u062c\u062d \u0628\u064a\u0646 10 \u064820 \u0628\u0627\u0644\u0645\u0626\u0629 \u0645\u0646 \u0627\u0644\u062d\u0627\u0644\u0627\u062a.<\/p>\n<p>\u0627\u0644\u0637\u0631\u064a\u0642\u0629 \u0627\u0644\u062b\u0627\u0644\u062b\u0629: \u062a\u0648\u0642\u064a\u0641 \u0627\u0644\u0645\u0628\u064a\u0636\u064a\u0646 \u0639\u0646 \u0627\u0644\u0639\u0645\u0644 \u0628\u0648\u0627\u0633\u0637\u0629 \u0627\u0628\u0631 \u0623\u062f\u0648\u064a\u0629 \u062a\u0639\u0637\u0644 \u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0646\u062e\u0627\u0645\u064a\u0629 \u062a\u0639\u0637\u0649 \u0641\u064a \u0623\u0648\u0644 \u064a\u0648\u0645 \u0644\u0627\u0628\u062a\u062f\u0627\u0621 \u0627\u0644\u062f\u0648\u0631\u0629 \u0627\u0644\u0634\u0647\u0631\u064a\u0629 \u0648\u0645\u0641\u0639\u0648\u0644\u0647\u0627 \u064a\u0628\u062f\u0623 \u062e\u0644\u0627\u0644 \u0623\u0648\u0644 \u0634\u0647\u0631\u064a\u0646.<\/p>\n<p>\u062b\u0627\u0646\u064a\u0627: \u0628\u0639\u062f \u0642\u0637\u0639 \u0623\u0648 \u062a\u0648\u0642\u064a\u0641 \u0645\u0635\u062f\u0631 \u0627\u0646\u062a\u0627\u062c \u0627\u0644\u0627\u0633\u062a\u0631\u0648\u062c\u064a\u0646\u060c \u064a\u062a\u0645 \u0625\u0639\u0637\u0627\u0621 \u0627\u0644\u0645\u0631\u064a\u0636\u0629 \u062f\u0648\u0627\u0621 \u062a\u0627\u0645\u0648\u0643\u0633\u064a\u0641\u064a\u0646 Tamoxifen \u0627\u0644\u0645\u0636\u0627\u062f \u0644\u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0627\u0644\u0627\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u0627\u0644\u0646\u0633\u0627\u0626\u064a\u0629. \u0623\u062b\u0628\u062a\u062a \u062f\u0631\u0627\u0633\u0627\u062a \u062d\u062f\u064a\u062b\u0629 \u0623\u0646 \u0623\u0641\u0636\u0644 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0627\u0644\u0639\u0644\u0627\u062c\u064a\u0629 \u0647\u064a \u0645\u0639 \u0642\u0637\u0639 \u0627\u0646\u062a\u0627\u062c \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0627\u0644\u0646\u0633\u0627\u0626\u064a\u0629 \u0648\u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u062a\u0627\u0645\u0648\u0643\u0633\u064a\u0641\u064a\u0646 \u0645\u0639 \u0628\u0639\u0636\u0647\u0645.<\/p>\n<p>\u0639\u0646\u062f\u0645\u0627 \u0644\u0627 \u064a\u0639\u0648\u062f \u0647\u0646\u0627\u0643 \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0639\u0644\u0649 \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0627\u0644\u0646\u0633\u0627\u0626\u064a\u0629\u060c \u0623\u0648 \u0639\u0646\u062f\u0645\u0627 \u064a\u0643\u0648\u0646 \u0627\u0644\u0648\u0631\u0645 \u0633\u0631\u064a\u0639\u0627\u064b \u0623\u0648 \u0645\u0646\u062a\u0634\u0631\u0627\u064b \u0641\u064a \u0627\u0644\u0627\u062d\u0634\u0627\u0621\u060c \u062a\u0635\u0628\u062d \u0627\u0644\u0645\u0631\u064a\u0636\u0629 \u0628\u062d\u0627\u062c\u0629 \u0625\u0644\u0649 \u0639\u0644\u0627\u062c \u0643\u064a\u0645\u064a\u0627\u0626\u064a.<\/p>\n<h2>\u0628 &#8211; \u0639\u0644\u0627\u062c \u0627\u0644\u0645\u0631\u064a\u0636\u0629 \u0627\u0644\u062a\u064a \u0623\u0635\u0628\u062d\u062a \u0641\u0648\u0642 \u0633\u0646 \u0627\u0646\u0642\u0637\u0627\u0639 \u0627\u0644\u062d\u064a\u0636 \u0645\u064a\u0646\u0648\u0628\u0648\u0632 Menopause<\/h2>\n<p>\u064a\u062a\u0645 \u0627\u0644\u0639\u0644\u0627\u062c \u0628\u0646\u0641\u0633 \u0627\u0644\u0637\u0631\u0642 \u0648\u0627\u0644\u062e\u0637\u0648\u0627\u062a \u0627\u0644\u0645\u0628\u064a\u0646\u0629 \u0623\u0639\u0644\u0627\u0647 \u0628\u062f\u0621\u0627\u064b \u0645\u0646 \u0627\u0644\u062e\u0637\u0648\u0629 \u0627\u0644\u062b\u0627\u0646\u064a\u0629 \u0644\u0623\u0646\u0647 \u0644\u0627 \u062d\u0627\u062c\u0629 \u0644\u0625\u0633\u062a\u0626\u0635\u0627\u0644 \u0627\u0644\u0645\u0628\u064a\u0636\u064a\u0646 \u062d\u064a\u062b \u0623\u0646\u0647\u0645\u0627 \u064a\u0643\u0648\u0646\u0627\u0646 \u0625\u0645\u0627 \u062a\u0648\u0642\u0641\u0627 \u0639\u0646 \u0627\u0644\u0639\u0645\u0644 \u0623\u0648 \u0641\u064a \u0637\u0631\u064a\u0642\u0647\u0645\u0627 \u0627\u0644\u062a\u062f\u0631\u064a\u062c\u064a \u0644\u0644\u062a\u0648\u0642\u0641 \u0627\u0644\u0643\u0627\u0645\u0644 \u0639\u0646 \u0627\u0644\u0639\u0645\u0644. \u0648\u0628\u064a\u0646\u062a \u0627\u0644\u062f\u0631\u0627\u0633\u0627\u062a \u0627\u0644\u0639\u062f\u064a\u062f\u0629 \u0623\u0646 \u0645\u0648\u0642\u0641\u0627\u062a \u0627\u0644\u0627\u0631\u0648\u0645\u0627\u062a\u0627\u0632 (Aromatase Inhibitors: AI) \u0644\u0647\u0627 \u0645\u0641\u0639\u0648\u0644 \u0623\u0641\u0636\u0644 \u0645\u0646 \u062a\u0627\u0645\u0648\u0643\u0633\u064a\u0641\u064a\u0646.<\/p>\n<p>\u0623\u0648\u0644\u0627\u064b: \u0623\u062f\u0648\u064a\u0629 \u0645\u0648\u0642\u0641\u0627\u062a \u0627\u0644\u0627\u0631\u0648\u0645\u0627\u062a\u0627\u0632<\/p>\n<p>\u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0645\u0648\u0642\u0641\u0627\u062a \u0627\u0644\u0627\u0631\u0648\u0645\u0627\u062a\u0627\u0632 \u0628\u0639\u062f \u0633\u0646 \u0627\u0646\u0642\u0637\u0627\u0639 \u0627\u0644\u062d\u064a\u0636 \u0627\u0644\u062a\u0627\u0645 \u0623\u0648 \u062a\u0648\u0642\u064a\u0641 \u0627\u0644\u0645\u0628\u064a\u0636\u064a\u0646 \u0627\u0644\u0643\u0627\u0645\u0644 \u0627\u0644\u0645\u0624\u0643\u062f \u0639\u0646 \u0627\u0644\u0639\u0645\u0644:<\/p>\n<p>\u0641\u064a \u0627\u0644\u0645\u0627\u0636\u064a \u0648\u0628\u0639\u062f \u0627\u0646\u062a\u0647\u0627\u0621 \u0639\u0645\u0644 \u0627\u0644\u0645\u0628\u064a\u0636 \u0643\u0646\u0627 \u0646\u0633\u062a\u0623\u0635\u0644 \u0627\u0644\u063a\u062f\u062f \u0641\u0648\u0642 \u0627\u0644\u0643\u0644\u0648\u062a\u0628\u064a\u0646 (Adrenalectomy) \u062b\u0645 \u0623\u0635\u0628\u062d\u0646\u0627 \u0646\u0639\u0637\u064a \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0644\u0642\u0637\u0639 \u0639\u0645\u0644 \u0647\u0630\u0647 \u0627\u0644\u063a\u062f\u062f. \u0627\u0628\u062a\u062f\u0623\u0646\u0627 \u0628\u0627\u0633\u062a\u0639\u0645\u0627\u0644 Aminoglutethemide \u0623\u0645\u064a\u0646\u0648\u063a\u0644\u0648\u062b\u064a\u062a\u0627\u0645\u0627\u064a\u062f (\u064a\u0648\u0644\u064a\u0643\u0633\u064a\u0646) \u0627\u0644\u0630\u064a \u064a\u0642\u0637\u0639 \u0627\u0644\u062a\u062d\u0648\u064a\u0644 \u0625\u0644\u0649 \u0627\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u0648\u0644\u0643\u0646\u0647 \u0623\u064a\u0636\u0627\u064b \u064a\u0642\u0637\u0639 \u0627\u0646\u062a\u0627\u062c \u0627\u0644\u0643\u0648\u0631\u062a\u064a\u0632\u0648\u0646 \u0645\u0646 \u063a\u062f\u062f \u0627\u0644\u0623\u062f\u0631\u064a\u0646\u0627\u0644 \u0641\u064a\u062a\u0648\u062c\u0628 \u0639\u0644\u064a\u0646\u0627 \u0625\u0639\u0637\u0627\u0621 \u0627\u0644\u0645\u0631\u064a\u0636\u0629 \u0645\u0627\u062f\u0629 \u0643\u0648\u0631\u062a\u064a\u0632\u0648\u0646 \u0627\u0644\u0623\u0633\u0627\u0633\u064a\u0629 \u0644\u0644\u062d\u064a\u0627\u0629. \u0623\u0645\u0627 \u062d\u0627\u0644\u064a\u0627\u064b \u0641\u0642\u062f \u062a\u0645 \u0627\u0643\u062a\u0634\u0627\u0641 \u0645\u0648\u0627\u062f \u062a\u0648\u0642\u064a\u0641\/\u0627\u0631\u0648\u0645\u0627\u062a\u0627\u0632- \u0623\u062c\u064a\u0627\u0644 \u062c\u062f\u064a\u062f\u0629 \u0646\u0633\u0645\u064a\u0647\u0627 New Generation Specific Aromatase Inhibitors (AI: Letrozole, Anastrozole, and Exemestene).<\/p>\n<p>\u0625\u0646 \u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u062a\u0642\u0637\u0639 \u0627\u0646\u062a\u0627\u062c \u0627\u0644\u0627\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u0641\u064a \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u0637\u0631\u0641\u064a\u0629 \u0628\u0639\u062f \u0627\u0646\u0642\u0637\u0627\u0639 \u0639\u0645\u0644 \u0627\u0644\u0645\u0628\u064a\u0636 \u0639\u0646\u062f\u0645\u0627 \u064a\u0635\u0628\u062d \u0627\u0644\u0645\u0635\u062f\u0631 \u0627\u0644\u0631\u0626\u064a\u0633\u064a \u0644\u0644\u0627\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u0639\u0646\u062f \u0627\u0644\u0645\u0631\u0623\u0629 \u0647\u0648 \u062a\u062d\u0648\u064a\u0644 \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0627\u0644\u0630\u0643\u0648\u0631\u064a\u0629 androstenedione \u0627\u0646\u062f\u0631\u0648\u0633\u062a\u064a\u0646\u062f\u064a\u0648\u0646 \u0641\u064a \u0627\u0644\u0623\u0646\u0633\u062c\u0629 \u0627\u0644\u0637\u0631\u0641\u064a\u0629 \u0645\u062b\u0644 \u0627\u0644\u0639\u0636\u0644 \u0648\u0627\u0644\u062f\u0647\u0646 \u0648\u0627\u0644\u062c\u0644\u062f \u0648\u0627\u0644\u0623\u0639\u0635\u0627\u0628\u060c \u0625\u0644\u0649 \u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0646\u0633\u0627\u0626\u064a\u0629 \u0627\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u0628\u0648\u0627\u0633\u0637\u0629 \u0645\u0627\u062f\u0629 \u0623\u0646\u0640\u0632\u064a\u0645 \u0627\u0633\u0645\u0647\u0627 \u062e\u0645\u064a\u0631\u0629 \u0623\u0631\u0648\u0645\u0627\u062a\u0627\u0632 ((Aromatase Inhibitors.<\/p>\n<p>\u0623\u0646\u0648\u0627\u0639 \u0645\u0648\u0642\u0641\u0627\u062a \u0627\u0644\u0623\u0631\u0648\u0645\u0627\u062a\u0627\u0632:<\/p>\n<p>1-\u00a0 \u0645\u0648\u0642\u0641 \u0627\u0644\u0623\u0631\u0648\u0645\u0627\u062a\u0627\u0632 \u0627\u0644\u063a\u064a\u0631 \u0627\u0644\u0633\u062a\u064a\u0631\u0648\u064a\u062f\u064a \u0646\u0648\u0639 2 \u0645\u062b\u0644 \u0623\u0646\u0627\u0633\u062a\u0631\u0648\u0632\u0648\u0644 (\u0623\u0631\u064a\u0645\u064a\u062f\u064a\u0643\u0633 Arimidex) \u0645\u0648\u0642\u0641 \u0648\u0644\u064a\u062a\u0631\u0648\u0632\u0648\u0644 (\u0641\u064a\u0645\u0627\u0631\u0627 Femara) \u0627\u0644\u0644\u0630\u064a\u0646 \u064a\u0644\u062a\u0635\u0642\u0627\u0646 \u0628\u062e\u0645\u064a\u0631\u0629 \u0623\u0631\u0648\u0645\u0627\u062a\u0627\u0632 \u0628\u0634\u0643\u0644 \u0642\u0627\u0628\u0644 \u0644\u0644\u0627\u0646\u062d\u0644\u0627\u0644.<\/p>\n<p>2-\u00a0 \u0645\u0648\u0642\u0641 \u0627\u0644\u0623\u0631\u0648\u0645\u0627\u062a\u0627\u0632 \u0627\u0644\u0633\u062a\u064a\u0631\u0648\u064a\u062f\u064a \u0623\u064a\u0643\u0632\u064a\u0645\u064a\u0633\u062a\u0627\u0646 (\u0623\u0631\u0648\u0645\u0627\u0632\u064a\u0646: Aromasin) \u0627\u0644\u0630\u064a \u064a\u0631\u0628\u0637 \u062e\u0645\u064a\u0631\u0629 \u0623\u0631\u0648\u0645\u0627\u062a\u0627\u0632 \u0628\u0634\u0643\u0644 \u0646\u0648\u0639 1 \u063a\u064a\u0631 \u0642\u0627\u0628\u0644 \u0644\u0644\u0627\u0646\u062d\u0644\u0627\u0644. \u0647\u0630\u0647 \u0627\u0644\u0645\u0648\u0627\u062f \u0645\u0641\u0639\u0648\u0644\u0647\u0627 \u0627\u0644\u0633\u0631\u064a\u0631\u064a \u0645\u062a\u0642\u0627\u0631\u0628 \u0648\u0647\u064a \u062a\u0642\u0637\u0639 \u0627\u0646\u062a\u0627\u062c \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0627\u0644\u0646\u0633\u0627\u0626\u064a\u0629 \u0648\u0644\u0627 \u062a\u0642\u0637\u0639 \u0627\u0646\u062a\u0627\u062c \u0627\u0644\u0643\u0648\u0631\u062a\u064a\u0632\u0648\u0646 \u0627\u0644\u0641\u064a\u0632\u064a\u0648\u0644\u0648\u062c\u064a.<\/p>\n<p>\u0648\u0646\u0634\u064a\u0631 \u0625\u0644\u0649 \u0623\u0646\u0647 \u0623\u0635\u0628\u062d \u0647\u0646\u0627\u0643 \u0623\u062f\u0648\u064a\u0629 \u0645\u0648\u0642\u0641\u0627\u062a \u0623\u0631\u0648\u0645\u0627\u062a\u0627\u0632 \u062c\u064a\u0646\u064a\u0631\u064a\u0643\u060c \u064a\u0645\u0643\u0646 \u0627\u0633\u062a\u0639\u0645\u0627\u0644\u0647\u0627 \u0628\u0639\u062f \u0627\u0644\u062a\u0623\u0643\u062f \u0645\u0646 \u0641\u0639\u0627\u0644\u064a\u062a\u0647\u0627 \u0648\u0646\u0648\u0639\u064a\u0629 \u0645\u0635\u0627\u062f\u0631 \u0648\u0628\u0644\u0627\u062f \u0625\u0646\u062a\u0627\u062c\u0647\u0627.<\/p>\n<p>\u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u0627\u0644\u062c\u062f\u064a\u062f\u0629 \u0644\u064a\u0633 \u0644\u0647\u0627 \u0645\u0641\u0639\u0648\u0644 \u0627\u0644\u0627 \u0628\u0639\u062f \u062a\u0648\u0642\u0641 \u0627\u0644\u0645\u0628\u064a\u0636 \u0639\u0646 \u0627\u0644\u0639\u0645\u0644\u060c \u0648\u0646\u0634\u062f\u062f \u0623\u0646\u0647\u0627 \u062a\u0639\u0637\u0649 \u0641\u0642\u0637 \u0644\u0644\u0645\u0631\u0636\u0649 \u0628\u0639\u062f \u0633\u0646 \u0627\u0646\u0642\u0637\u0627\u0639 \u0627\u0644\u062d\u064a\u0636 \u0648\u0644\u064a\u0633 \u062e\u0644\u0627\u0644\u0647 \u0648\u0644\u0627 \u0642\u0628\u0644\u0647\u060c \u0625\u0644\u0627 \u0625\u0630\u0627 \u062a\u0645 \u0625\u0633\u062a\u0626\u0635\u0627\u0644 \u0627\u0644\u0645\u0628\u064a\u0636\u064a\u0646 \u0623\u0648 \u062a\u0645 \u062a\u0639\u0637\u064a\u0644\u0647\u0645\u0627 \u0628\u0648\u0627\u0633\u0637\u0629 \u0627\u0644\u0623\u0634\u0639\u0629 \u0623\u0648 \u0628\u0648\u0627\u0633\u0637\u0629 \u062a\u0639\u0637\u064a\u0644 \u0627\u0644\u063a\u062f\u0629 \u0627\u0644\u0646\u062e\u0627\u0645\u064a\u0629 \u0628\u0648\u0627\u0633\u0637\u0629 \u0623\u062f\u0648\u064a\u0629 \u0645\u062b\u0644 &#8220;\u0645\u062b\u064a\u0644\u0627\u062a \u0627\u0644\u0640-\u0627\u062a\u0634-\u0627\u0631- \u0627\u062a\u0634&#8221; LHRH analogs \u0632\u0648\u0644\u0627\u062f\u064a\u0643\u0633 \u0623\u0648 \u062f\u064a\u0643\u0627\u0628\u064a\u0628\u062a\u064a\u0644 \u0623\u0648 \u0628\u0631\u0648\u0641\u0627\u0643\u062a \u0623\u0648 \u063a\u064a\u0631\u0647.<\/p>\n<p>\u0623\u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646\u062a \u0627\u0644\u0633\u064a\u062f\u0629 \u0627\u0644\u0645\u0631\u064a\u0636\u0629 \u0641\u064a \u0645\u0631\u062d\u0644\u0629 \u0627\u0628\u062a\u062f\u0627\u0621 \u0627\u0646\u0642\u0637\u0627\u0639 \u0627\u0644\u062d\u064a\u0636 \u0641\u064a\u062c\u0628 \u0625\u0639\u0637\u0627\u0621 \u062a\u0627\u0645\u0648\u0643\u0633\u064a\u0641\u064a\u0646 \u0648\u064a\u062a\u0648\u062c\u0628 \u062a\u0634\u062e\u064a\u0635 \u0628\u0644\u0648\u063a \u0633\u0646 \u0627\u0646\u0642\u0637\u0627\u0639 \u0627\u0644\u062d\u064a\u0636 \u0628\u0648\u0627\u0633\u0637\u0629 \u0625\u062c\u0631\u0627\u0621 \u0641\u062d\u0648\u0635\u0627\u062a \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0627\u0644\u0646\u0633\u0627\u0626\u064a\u0629 \u0648\u0627\u0644\u062a\u0623\u0643\u062f \u0628\u0623\u0646 \u0645\u0633\u062a\u0648\u0649 \u0627\u0644\u0623\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u0623\u0633\u062a\u0631\u0627\u062f\u064a\u0648\u0644 (Estradiol) \u0642\u0644\u064a\u0644\u0627\u064b \u062c\u062f\u0627\u064b \u0641\u064a \u0627\u0644\u062f\u0645\u060c \u0648\u0623\u0646 \u0623\u0644 \u0623\u062a\u0634 (LH) \u0648\u0627\u0641 \u0623\u0633 \u0623\u062a\u0634 (FSH) \u0623\u0635\u0628\u062d\u0627 \u0639\u0627\u0644\u064a\u064a\u0646 \u0643\u062b\u064a\u0631\u0627\u064b. \u064a\u062c\u0628 \u0625\u0639\u0627\u062f\u0629 \u0627\u0644\u0641\u062d\u0635 \u0628\u0639\u062f \u0633\u062a\u0629 \u0623\u0634\u0647\u0631 \u0648\u0644\u0645\u062f\u0629 \u0633\u0646\u0629 \u0648\u062a\u0648\u0642\u0641 \u0627\u0644\u062f\u0648\u0631\u0629 \u0627\u0644\u0634\u0647\u0631\u064a\u0629 \u0644\u0645\u062f\u0629 \u0633\u0646\u062a\u064a\u0646 \u0642\u0628\u0644 \u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0645\u0648\u0642\u0641\u0627\u062a \u0627\u0644\u0623\u0631\u0648\u0645\u0627\u062a\u0627\u0632.<\/p>\n<p>\u062b\u0627\u0646\u064a\u0627\u064b: \u062a\u0627\u0645\u0648\u0643\u0633\u064a\u0641\u064a\u0646<\/p>\n<p>\u062b\u0627\u0644\u062b\u0627\u064b: \u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u062f\u0648\u0627\u0621 \u0645\u0636\u0627\u062f \u0644\u0645\u062a\u0644\u0642\u0628\u0627\u062a \u0627\u0633\u062a\u0631\u0648\u062c\u0628\u0646: \u0641\u0648\u0644\u0641\u064a\u0633\u062a\u0631\u0627\u0646\u062a (\u0641\u0627\u0633\u0644\u0648\u062f\u064a\u0643\u0633): Fulvestrant (Faslodex) \u0647\u0630\u0627 \u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u062d\u062f\u064a\u062b \u064a\u062a\u0645 \u0625\u0639\u0637\u0627\u0626\u0647 \u0628\u0634\u0643\u0644 \u0625\u0628\u0631\u0629 \u062e\u0627\u0635\u0629 \u0639\u0645\u064a\u0642\u0629 \u0632\u064a\u063a\u0632\u0627\u063a \u0628\u0627\u0644\u0639\u0636\u0644 \u0648\u062a\u0645 \u062d\u062f\u064a\u062b\u0627\u064b \u0627\u0644\u062a\u0623\u0643\u062f \u0623\u0646\u0647 \u0645\u0646 \u0627\u0644\u0623\u0641\u0636\u0644 \u0625\u0639\u0637\u0627\u0621 \u062c\u0631\u0639\u0629 500 \u0645\u063a\u0645 \u0641\u064a \u0627\u0644\u064a\u0648\u0645 \u0627\u0644\u0623\u0648\u0644 \u064815 \u064828 \u062b\u0645 \u0645\u0631\u0629 \u0643\u0644 \u0634\u0647\u0631.<\/p>\n<p>\u0631\u0627\u0628\u0639\u0627\u064b: \u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0645\u0627\u062f\u0629 \u0627\u0644\u0628\u0631\u0648\u062c\u0633\u062a\u064a\u0631\u0648\u0646 Progesterone \u0627\u0644\u0645\u0646\u062a\u062c\u0629 \u062c\u0632\u0626\u064a\u0627\u064b \u0641\u064a \u0627\u0644\u0645\u062e\u062a\u0628\u0631 (semi-synthetic) \u0645\u062b\u0644 \u0645\u064a\u062c\u064a\u0633\u062a\u064a\u0631\u0648\u0644 \u0627\u0633\u064a\u062a\u0627\u062a (\u0645\u064a\u063a\u0627\u0633) \u0628\u0634\u0643\u0644 \u062d\u0628\u0648\u0628.<\/p>\n<p>\u062e\u0627\u0645\u0633\u0627\u064b: \u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0627\u0644\u0630\u0643\u0631\u064a\u0629 \u0644\u062a\u0648\u0642\u064a\u0641 \u0646\u0645\u0648 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 \u0644\u0644\u062b\u062f\u064a.<\/p>\n<p>\u0633\u0627\u062f\u0633\u0627\u064b: \u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0627\u0644\u0627\u064a\u0633\u062a\u0631\u0648\u062c\u064a\u0646: \u0628\u0639\u0636 \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0642\u062f \u062a\u0633\u062a\u062c\u064a\u0628 \u0641\u064a \u0646\u0647\u0627\u064a\u0629 \u0627\u0644\u0645\u0637\u0627\u0641 \u062d\u062a\u0649 \u0639\u0644\u0649 \u0627\u0644\u0627\u0633\u062a\u0631\u0648\u062c\u064a\u0646.<\/p>\n<p>\u0633\u0627\u0628\u0639\u0627\u064b: \u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0645\u0648\u0642\u0641\u0627\u062a \u0627\u0645-\u062a\u0648\u0631:<\/p>\n<p>\u0623\u0628\u062d\u0627\u062b \u062c\u062f\u064a\u062f\u0629 \u062d\u0648\u0644 \u0627\u0633\u062a\u0639\u0627\u062f\u0629 \u0627\u0644\u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0639\u0644\u0649 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u064a \u0639\u0646 \u0637\u0631\u064a\u0642 \u0625\u0636\u0627\u0641\u0629 \u0623\u062f\u0648\u064a\u0629 \u0645\u0647\u062f\u0641\u0629 \u0636\u062f \u0627\u0646\u0640\u0632\u064a\u0645\u0627\u062a \u0628\u0631\u0648\u062a\u064a\u0646 \u0627\u0645-\u062a\u0648\u0631:(mTOR) \u0647\u0646\u0627\u0643 \u0646\u062a\u0627\u0626\u062c \u0623\u0628\u062d\u0627\u062b \u062c\u062f\u064a\u062f\u0629 ((BOLERO-2 \u062d\u0648\u0644 &#8220;\u062f\u0631\u0648\u0628 \u0627\u0644\u062a\u0643\u0627\u062b\u0631 \u062f\u0627\u062e\u0644 \u0627\u0644\u062e\u0644\u0627\u064a\u0627 \u0627\u0644\u0633\u0631\u0637\u0627\u0646\u064a\u0629 Proliferation pathways&#8221; \u062a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0627\u0647\u0645\u064a\u0629 \u062f\u0631\u0628 PI3K-mTOR-AKT \u0648\u062a\u0641\u0627\u0639\u0644\u0647 \u0645\u0639 \u062f\u0631\u0628 \u0627\u0644\u0627\u0633\u062a\u0631\u0648\u062c\u064a\u0646\u060c \u062a\u0628\u064a\u0646 \u0623\u0646 \u0627\u064a\u0642\u0627\u0641 \u0647\u0630\u0647 \u0627\u0644\u062f\u0631\u0648\u0628 \u0639\u0646 \u0627\u0644\u0639\u0645\u0644 \u0628\u0648\u0627\u0633\u0637\u0629 \u062f\u0648\u0627\u0621 \u0627\u064a\u0641\u064a\u0631\u0648\u0644\u064a\u0645\u0648\u0633 (\u0627\u0641\u064a\u0646\u064a\u062a\u0648\u0631: Everolimus-RAD001-Afinitor) \u064a\u0632\u064a\u062f \u0645\u0646 \u0627\u0633\u062a\u062c\u0627\u0628\u0629 \u0627\u0644\u0645\u0631\u064a\u0636\u0629 \u0639\u0644\u0649 \u062f\u0648\u0627\u0621 \u0627\u064a\u0643\u0632\u0645\u064a\u0633\u062a\u064a\u0646 \u0641\u064a \u0627\u0644\u062d\u0627\u0644\u0627\u062a \u0627\u0644\u0645\u0646\u062a\u0634\u0631\u0629 \u062d\u062a\u0649 \u0628\u0639\u062f \u0623\u0646 \u062a\u0643\u0648\u0646 \u0627\u0633\u062a\u0639\u0645\u0644\u062a \u0627\u0644\u0633\u064a\u062f\u0629 \u062f\u0648\u0627\u0621 \u0644\u064a\u062a\u0631\u0648\u0632\u0648\u0644 \u0623\u0648 \u0627\u0646\u0627\u0633\u062a\u0631\u0648\u0632\u0648\u0644. \u0627\u0646 \u0647\u0630\u0647 \u0627\u0644\u0646\u062a\u0627\u0626\u062c \u0648\u0627\u0639\u062f\u0629 \u0628\u062a\u0642\u062f\u0645 \u062c\u062f\u064a\u062f \u064a\u0632\u064a\u062f \u0645\u0646 \u0645\u0641\u0639\u0648\u0644 \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0648\u064a\u0637\u064a\u0644 \u0645\u062f\u0629 \u0627\u0633\u062a\u0639\u0645\u0627\u0644\u0647\u0627 \u0642\u0628\u0644 \u0627\u0644\u0644\u062c\u0648\u0621 \u0625\u0644\u0649 \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0643\u064a\u0645\u0627\u0626\u064a. \u0647\u0646\u0627\u0643 \u0623\u0628\u062d\u0627\u062b \u0639\u062f\u064a\u062f\u0629 \u062c\u062f\u064a\u062f\u0629 \u062d\u0648\u0644 \u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0627\u064a\u0641\u064a\u0631\u0648\u0644\u064a\u0645\u0648\u0633 \u0645\u0639 \u062a\u0627\u0645\u0648\u0643\u0633\u064a\u0641\u064a\u0646 \u0623\u0648 \u0645\u0648\u0642\u0641\u0627\u062a \u0627\u0644\u0623\u0631\u0648\u0645\u0627\u062a\u0627\u0631 \u0648\u0623\u064a\u0636\u0627\u064b \u0645\u0642\u0627\u0631\u0646\u062a\u0647\u0627 \u0645\u0639 \u062d\u0628\u0648\u0628 \u0639\u0644\u0627\u062c \u0643\u064a\u0645\u064a\u0627\u0626\u064a \u062a\u062c\u0628 \u0645\u062a\u0627\u0628\u0639\u0629 \u0646\u062a\u0627\u0626\u062c\u0647\u0627.<\/p>\n<p>\u062b\u0627\u0645\u0646\u0627\u064b: \u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0645\u0648\u0642\u0641\u0627\u062a \u0627\u0631\u0648\u0645\u0627\u062a\u0627\u0632 \u0645\u0639 \u0645\u0636\u0627\u062f\u0627\u062a \u0647\u064a\u06312:<\/p>\n<p>\u0623\u0645\u0627 \u0625\u0630\u0627 \u0643\u0627\u0646 \u0627\u0644\u0648\u0631\u0645 \u064a\u062d\u062a\u0648\u064a \u0639\u0644\u0649 \u0645\u062a\u0644\u0642\u064a\u0627\u062a \u0647\u064a\u06312 (HER 2) \u0628\u0627\u0644\u0625\u0636\u0627\u0641\u0629 \u0625\u0644\u0649 \u0627\u0644\u0645\u062a\u0644\u0642\u064a\u0627\u062a \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u064a\u0629 \u0627\u0644\u0646\u0633\u0627\u0626\u064a\u0629\u060c \u0641\u0647\u0646\u0627\u0643 \u0623\u0628\u062d\u0627\u062b\u0627 \u0633\u0631\u064a\u0631\u064a\u0629 \u062c\u062f\u064a\u062f\u0629 \u062a\u0634\u064a\u0631 \u0625\u0644\u0649 \u0627\u0646 \u0627\u0644\u0645\u0631\u064a\u0636\u0629 \u0645\u0627 \u0628\u0639\u062f \u0633\u0646 \u0627\u0646\u0642\u0637\u0627\u0639 \u0627\u0644\u062d\u064a\u0636 \u0645\u064a\u0646\u0648\u0628\u0648\u0632\u060c \u0642\u062f \u062a\u0633\u062a\u0641\u064a\u062f \u0645\u0646 \u0639\u0644\u0627\u062c \u0623\u062f\u0648\u064a\u0629 \u062a\u0648\u0642\u064a\u0641 \u0627\u0644\u0627\u0631\u0648\u0645\u0627\u062a\u0627\u0632 \u0645\u0639 \u0645\u0636\u0627\u062f\u0627\u062a \u0636\u062f \u0647\u064a\u06312. \u0647\u0646\u0627\u0643 \u062f\u0631\u0627\u0633\u0629 \u062a\u0627\u0646\u062f\u064a\u0645 (TANDEM) \u0627\u0644\u062a\u064a \u0623\u062b\u0628\u062a\u062a \u0641\u0639\u0627\u0644\u064a\u0629 \u0627\u0646\u0627\u0633\u062a\u0631\u0648\u0632\u0648\u0644 (\u0627\u0631\u064a\u0645\u064a\u062f\u064a\u0643\u0633) \u0645\u0639 \u062a\u0631\u0627\u0633\u062a\u0648\u0632\u0648\u0645\u0627\u0628 (\u0647\u064a\u0631\u0633\u0628\u062a\u064a\u0646)\u060c \u0648\u0647\u0646\u0627\u0643 \u062f\u0631\u0627\u0633\u0629 EGF 30008 \u0623\u062b\u0628\u062a\u062a \u0641\u0639\u0627\u0644\u064a\u0629 \u0644\u064a\u062a\u0631\u0648\u0632\u0648\u0644 (\u0641\u064a\u0645\u0627\u0631\u0627) \u0645\u0639 \u0644\u0627\u0628\u0627\u062a\u064a\u0646\u064a\u0628 (\u062a\u0627\u064a\u0643\u064a\u0631\u0628(. \u0644\u0642\u062f \u062a\u0645\u062a \u0645\u0648\u0627\u0641\u0642\u0629 \u0645\u0646\u0638\u0645\u0629 \u0627\u0644\u063a\u0630\u0627\u0621 \u0648\u0627\u0644\u062f\u0648\u0627\u0621 \u0627\u0644\u0623\u0645\u064a\u0631\u0643\u064a\u0629 FDA \u0648\u0627\u0644\u0623\u0648\u0631\u0648\u0628\u064a\u0629 EMEA \u0639\u0644\u0649 \u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0645\u0636\u0627\u062f\u0627\u062a \u0627\u0644\u0647\u064a\u0631 2 \u0645\u0639 \u0645\u0648\u0642\u0641\u0648\u0627 \u0627\u0644\u0627\u0631\u0648\u0645\u0627\u062a\u0627\u0632 \u0644\u0639\u0644\u0627\u062c \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0627\u0644\u0645\u0646\u062a\u0634\u0631 \u0627\u0644\u0630\u064a \u064a\u062d\u062a\u0648\u064a \u0639\u0644\u0649 \u0645\u062a\u0644\u0642\u064a\u0627\u062a \u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0646\u0633\u0627\u0626\u064a\u0629 \u0648\u0647\u064a\u06312.<\/p>\n<h2>\u062c &#8211; \u0639\u0644\u0627\u062c \u0639\u0646\u062f \u0627\u0644\u0633\u064a\u062f\u0629 \u0627\u0644\u0645\u0631\u064a\u0636\u0629 \u062e\u0644\u0627\u0644 \u0633\u0646 \u0627\u0646\u0642\u0637\u0627\u0639 \u0627\u0644\u062d\u064a\u0636: \u0628\u064a\u0631\u064a &#8211; \u0645\u064a\u0646\u0648\u0628\u0648\u0632 Perimenopause<\/h2>\n<p>\u0623\u0645\u0627 \u0639\u0646\u062f \u0627\u0644\u0645\u0631\u064a\u0636\u0629 \u0627\u0644\u062a\u064a \u062a\u0643\u0648\u0646 \u0645\u0627 \u0632\u0627\u0644\u062a &#8220;\u062d\u0648\u0644 \u0627\u0644\u0645\u064a\u0646\u0648\u0628\u0648\u0632: peri-menopause&#8221; \u0641\u064a\u062c\u0628 \u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u062a\u0627\u0645\u0648\u0643\u0633\u064a\u0641\u064a\u0646 \u0623\u0648 \u0644\u0644\u0636\u0631\u0648\u0631\u0629 \u0625\u0639\u0637\u0627\u0621 LHRHa \u0645\u0639 \u0645\u0648\u0642\u0641\u0627\u062a \u0627\u0644\u0623\u0631\u0648\u0645\u0627\u062a\u0627\u0631 AI \u0648\u0644\u064a\u0633 \u0641\u0642\u0637 \u0645\u0648\u0642\u0641\u0627\u062a \u0627\u0644\u0627\u0631\u0648\u0645\u0627\u062a\u0627\u0632 \u0648\u062d\u062f\u0647\u0627.<\/p>\n<h2>\u0643\u064a\u0641 \u0646\u0633\u062a\u0637\u064a\u0639 \u062a\u0648\u0642\u064a\u0641 \u0627\u0644\u0645\u0628\u064a\u0636 \u0639\u0646 \u0627\u0644\u0639\u0645\u0644\u061f<\/h2>\n<p>\u0646\u0633\u062a\u0637\u064a\u0639 \u0630\u0644\u0643 \u0639\u0646 \u0637\u0631\u064a\u0642:<\/p>\n<p>1- \u0625\u062c\u0631\u0627\u0621 \u062c\u0631\u0627\u062d\u0629 \u0648\u0625\u0633\u062a\u0626\u0635\u0627\u0644 \u0644\u0644\u0645\u0628\u064a\u0636\u064a\u0646.<\/p>\n<p>2- \u062a\u0639\u0637\u064a\u0644 \u0627\u0644\u0645\u0628\u064a\u0636\u064a\u0646 \u0639\u0646 \u0627\u0644\u0639\u0645\u0644 \u0628\u0648\u0627\u0633\u0637\u0629 \u0627\u0644\u0639\u0644\u0627\u062c \u0628\u0627\u0644\u0623\u0634\u0639\u0629 \u0648\u0627\u0644\u062a\u0623\u0643\u062f \u0645\u0646 \u0627\u0644\u0646\u062a\u064a\u062c\u0629.<\/p>\n<p>3- \u0625\u0639\u0637\u0627\u0621 \u0623\u062f\u0648\u064a\u0629 \u0647\u0631\u0645\u0648\u0646\u064a\u0629 \u0628\u062f\u064a\u0644\u0629 \u0648\u0645\u0648\u0627\u0632\u064a\u0629 \u0644\u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0627\u0644\u063a\u062f\u062f \u0627\u0644\u0646\u062e\u0627\u0645\u064a\u0629 LHRH analogs \u0645\u062b\u0644 Leuprolide (\u0625\u0628\u0631\u0629 \u0628\u0627\u0644\u0639\u0636\u0644) \u0623\u0648 \u062f\u064a\u0643\u0627\u0628\u0628\u064a\u0628\u062a\u064a\u0644 Decapeptyl (\u0625\u0628\u0631\u0629 \u0628\u0627\u0644\u0639\u0636\u0644) \u0623\u0648 Zoladex (\u0625\u0628\u0631\u0629 \u0646\u0641\u0642 \u062a\u062d\u062a \u0627\u0644\u062c\u0644\u062f) \u062a\u0639\u0637\u0649 \u0645\u0631\u0629 \u0643\u0644 \u0634\u0647\u0631. \u0647\u0646\u0627\u0643 \u0623\u064a\u0636\u0627\u064b \u0645\u0633\u062a\u062d\u0636\u0631\u0627\u062a \u0645\u0645\u0627\u062b\u0644\u0629 \u062a\u0639\u0637\u0649 \u0645\u0631\u0629 \u0643\u0644 \u062b\u0644\u0627\u062b\u0629 \u0623\u0634\u0647\u0631. \u0647\u0630\u0647 \u0627\u0644\u0623\u062f\u0648\u064a\u0629 \u062a\u0633\u062a\u0637\u064a\u0639 \u0623\u0646 \u062a\u0648\u0642\u0641 \u0643\u0644 \u0627\u0646\u062a\u0627\u062c \u0644\u0644\u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0627\u0644\u0646\u0633\u0627\u0626\u064a\u0629.<\/p>\n<h2>\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u064a \u0644\u0644\u0645\u0631\u0627\u062d\u0644 \u0627\u0644\u0623\u0648\u0644\u064a\u0629<\/h2>\n<p>\u0648\u0646\u0642\u0635\u062f \u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u064a \u0641\u064a \u0627\u0644\u0645\u0631\u0627\u062d\u0644 \u0627\u0644\u0645\u0628\u0643\u0631\u0629 \u0644\u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0644\u0644\u0648\u0642\u0627\u064a\u0629 \u0628\u0639\u062f \u0627\u0644\u062c\u0631\u0627\u062d\u0629: Adjuvant Hormonal Therapy \u0648\u0627\u0644\u0639\u0644\u0627\u062c \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u064a \u0645\u0627 \u0642\u0628\u0644 \u0627\u0644\u062c\u0631\u0627\u062d\u0629 Neo-adjuvant therapy<\/p>\n<p>1 &#8211; \u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u0627\u0644\u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0627\u0644\u0645\u0636\u0627\u062f\u0629 \u0641\u064a \u0627\u0644\u0645\u0631\u0627\u062d\u0644 \u0627\u0644\u0623\u0648\u0644\u0649 \u0639\u0646\u062f \u0627\u0644\u0633\u064a\u062f\u0627\u062a \u0645\u0627 \u0642\u0628\u0644 \u0645\u064a\u0646\u0648\u0628\u0648\u0632 (pre-menopause).<\/p>\n<p>\u062a\u0627\u0645\u0648\u0643\u0633\u064a\u0641\u064a\u0646: \u062a\u0627\u0645\u0648\u0643\u0633\u064a\u0641\u064a\u0646 \u0647\u0648 \u062f\u0648\u0627\u0621 \u0645\u0636\u0627\u062f \u0644\u0644\u0647\u0631\u0645\u0648\u0646\u0627\u062a \u0627\u0644\u0646\u0633\u0627\u0626\u064a\u0629 \u0627\u064a\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u0648\u0644\u0647 \u0645\u0641\u0639\u0648\u0644 \u0636\u062f \u0633\u0631\u0637\u0627\u0646 \u0627\u0644\u062b\u062f\u064a \u0627\u0644\u0630\u064a \u064a\u062d\u062a\u0648\u064a \u0639\u0644\u0649 \u0645\u062a\u0644\u0642\u064a\u0627\u062a \u0627\u064a\u0633\u062a\u0631\u0648\u062c\u064a\u0646 \u062f\u0627\u062e\u0644 \u0646\u0648\u0627\u062a\u0647. 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\u062a\u0648\u0631\u064a\u0645\u064a\u0641\u064a\u0646<\/h2>\n<p>\u0647\u0630\u0627 \u0623\u064a\u0636\u0627\u064b \u062f\u0648\u0627\u0621 SERM \u0642\u0631\u064a\u0628 \u0645\u0646 \u062a\u0627\u0645\u0648\u0643\u0633\u064a\u0641\u064a\u0646 \u0648\u0644\u0647 \u0646\u0641\u0633 \u0627\u0644\u0645\u0641\u0639\u0648\u0644 \u0648\u0646\u0641\u0633 \u0635\u064a\u063a\u0629 \u0627\u0644\u0627\u0633\u062a\u0639\u0635\u0627\u0621 (Gross Resistance) \u0623\u064a \u0623\u0646 \u0625\u0630\u0627 \u0644\u0645 \u064a\u0639\u0645\u0644 \u0623\u062d\u062f\u0647\u0645 \u0641\u0644\u0646 \u064a\u0643\u0648\u0646 \u0647\u0646\u0627\u0643 \u0645\u0641\u0639\u0648\u0644 \u0644\u0644\u0627\u062e\u0631. \u0644\u0630\u0644\u0643 \u0644\u0627 \u064a\u062a\u0645 \u0627\u0633\u062a\u0639\u0645\u0627\u0644 \u062a\u0648\u0631\u064a\u0645\u064a\u0641\u064a\u0646 \u0643\u062b\u064a\u0631\u0627\u064b \u0648\u0647\u0648 \u0644\u064a\u0633 \u0645\u062a\u0648\u0641\u0631\u0627\u064b 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